Exploiting fluorescent zinc(ii) and copper(ii) complexes for enantiomeric excess determination of hydroxycarboxylates. Issue 63 (8th July 2020)

• Record Type: Journal Article
• Authors: Sheykhi, Sara; Mosca, Lorenzo; Pushina, Mariia; Dey, Kaustav; Anzenbacher, Pavel
• Is Part Of: Chemical communications. Volume 56:Issue 63(2020)
• Page Start: 8964
• Page End: 8967
• Publication Date: 2020-07-08
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc03437a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Fluorescent Zn(ii ) complexes with quinolino-1, 2-diaminocylohexane ligands recognize enantiomeric excess in scalemic mixtures of α-hydroxycarboxylates. Abstract : Chiral hydroxycarboxylates are useful compounds in the syntheses of natural products, pharmaceutical intermediates, and drugs. Here, we report on Zn- and Cu-containing sensors that can distinguish between enantiomers of hydroxycarboxylates through the quenching or the enhancement of fluorescence. A Zn-based sensor—[Zn RR L] 2+ —is used in an assay to perform analyses of enantiomeric excess (% ee) of scalemic mixtures of α-hydroxycarboxylates and various drugs including the statin drug atorvastatin. This assay enables determination of mixtures of enantiomers across the range from 0 to 100% ee.