Mixed alkoxy/hydroxy 1, 8-naphthalimides: expanded fluorescence colour palette and in vitro bioactivity. Issue 50 (20th May 2020)

• Record Type: Journal Article
• Authors: Rudebeck, Elley E.; Cox, Rosalind P.; Bell, Toby D. M.; Acharya, Rameshwor; Feng, Zikai; Gueven, Nuri; Ashton, Trent D.; Pfeffer, Frederick M.
• Is Part Of: Chemical communications. Volume 56:Issue 50(2020)
• Page Start: 6866
• Page End: 6869
• Publication Date: 2020-05-20
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc01251c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An efficient and functional group tolerant route to access hydroxy 1, 8-naphthalimides has been used to synthesise a range of mono- and disubstituted hydroxy-1, 8-naphthalimides with fluorescence emissions covering the visible spectrum. Abstract : An efficient and functional group tolerant route to access hydroxy 1, 8-naphthalimides has been used to synthesise a range of mono- and disubstituted hydroxy-1, 8-naphthalimides with fluorescence emissions covering the visible spectrum. The dialkoxy substituted compounds prepared possess high quantum yields (up to 0.95) and long fluorescent lifetimes (up to 14 ns). The method has been used to generate scriptaid analogues that successfully inhibit HDAC6 in vitro with tubulin acetylation assays confirming that these compounds are more effective than tubastatin.