Changes in serotype distribution and antimicrobial resistance of Streptococcus pneumoniae isolates from adult patients in Asia: Emergence of drug-resistant non-vaccine serotypes. Issue 38 (27th August 2020)

• Record Type: Journal Article
• Authors: Kim, So Hyun; Chung, Doo Ryeon; Song, Jae-Hoon; Baek, Jin Yang; Thamlikitkul, Visanu; Wang, Hui; Carlos, Celia; Ahmad, Norazah; Arushothy, Revathy; Tan, Si Huei; Lye, David; Kang, Cheol-In; Ko, Kwan Soo; Peck, Kyong Ran
• Is Part Of: Vaccine. Volume 38:Issue 38(2020)
• Page Start: 6065
• Page End: 6073
• Publication Date: 2020-08-27
• Subjects: S. pneumoniae -- Serotypes -- Antimicrobial resistance -- Non-PCV serotypes; PCV7 7-valent pneumococcal conjugate vaccine -- PCV10 10-valent pneumococcal conjugate vaccine -- PCV13 13-valent pneumococcal conjugate vaccine -- PPV23 23-valent pneumococcal polysaccharide vaccine -- MDR multidrug resistance; Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2019.09.065
• Languages: English
• ISSNs: 0264-410X

Abstract

Abstract: This study was performed to investigate the serotype distribution and antimicrobial susceptibility of Streptococcus pneumoniae in Asian countries. A prospective surveillance study on S. pneumoniae collected from adult patients (≥50 years old) with invasive pneumococcal disease or community-acquired pneumonia was performed at 66 hospitals in Asian countries (Korea, China, Malaysia, Singapore, the Philippines, and Thailand) in 2012-2017. Serotyping and antimicrobial susceptibility tests of 850 pneumococcal isolates were performed. The proportions of isolates with serotypes covered by 13-valent pneumococcal conjugate vaccine (PCV13) were 37.0% in Korea, 53.4% in China, 77.2% in Malaysia, 35.9% in the Philippines, 68.7% in Singapore, and 60.2% in Thailand. Major serotypes were 19F (10.4%), 19A (10.1%), and 3 (8.5%) in 2012-2017, with different serotype distributions in each country. Macrolide resistance in pneumococci was high (66.8%) and prevalence of multidrug resistance (MDR) also remained high (50.8%). MDR non-PCV13 serotypes such as 11A, 15A, 35B, and 23A have emerged in Asian countries. This study showed the persistent prevalence of 19F and 19A with a noteworthy increase of certain non-PCV13 serotypes in Asian countries. High prevalence of macrolide resistance and MDR was also found in pneumococcal isolates. These data emphasize the need for continued surveillance of pneumococcal epidemiology in Asia in the post-pneumococcal vaccine era.