Chemical purification of 111Ag from isobaric impurity 111Cd by solid phase extraction chromatography: a proof of concept study. (October 2020)

• Record Type: Journal Article
• Authors: Tosato, Marianna; Nardella, Sonia; Badocco, Denis; Pastore, Paolo; Andrighetto, Alberto; Realdon, Nicola; Di Marco, Valerio
• Is Part Of: Applied radiation and isotopes. Volume 164(2020:Oct.)
• Publication Date: 2020-10
• Subjects: Cadmium -- CL resin -- Extraction chromatography -- ISOLPHARM -- Silver; Radiology -- Periodicals; Radiation -- Industrial applications -- Periodicals; Nuclear chemistry -- Periodicals; Internet resource; Periodical; 660.298
• DOI: 10.1016/j.apradiso.2020.109263
• Languages: English
• ISSNs: 0969-8043

Abstract

Abstract: Silver-111 ( 111 Ag, t 1/2 = 7.47 d) is a β − emitter suitable for targeted cancer therapy due to favourable decay properties. The production of no-carrier added 111 Ag via Isotope Separation On-Line (ISOL) technique is being investigated at the Legnaro National Laboratories of the Italian Institute of Nuclear Physics (ISOLPHARM project). Stable Cadmium-111 ( 111 Cd) is co-produced as isobaric contaminant, hence a chemical separation process must be developed to selectively harvest 111 Ag. In this study, a chromatographic procedure employing the commercially available CL resin was investigated by using stable Ag + and Cd 2+ . Results indicate that CL resin allows to efficiently separate Ag + from Cd 2+ and recover the former with high yields. Highlights: Silver-111 ( t 1/2 = 7.47 days) is a β − emitting radionuclide suitable for cancer therapy. During 111 Ag production via ISOL method, 111 Cd is co-produced. Chromatographic method using commercially available CL resin was developed to separate silver from cadmium.