Farnesyl glycosides and one new triterpenoid saponin from the roots of Lecaniodiscus cupanioides Planch. ex Benth. (September 2020)

• Record Type: Journal Article
• Authors: Messi, Lin Marcellin; Noté, Olivier Placide; Mbing, Joséphine Ngo; Vansteelandt, Marieke; Lavedan, Pierre; Vedrenne, Marc; Pegnyemb, Dieudonné Emmanuel; Haddad, Mohamed
• Is Part Of: Carbohydrate research. Volume 495(2020)
• Publication Date: 2020-09
• Subjects: Lecaniodiscus cupanioides -- Sapindaceae -- Sesquiterpene glycosides -- Cupanioidesosides -- 2D NMR; Carbohydrates -- Periodicals; Chemistry, Organic -- Periodicals; Biochemistry -- Periodicals; Carbohydrates -- Periodicals; Chimie organique -- Périodiques; Glucides -- Périodiques; Biochemistry; Carbohydrates; Chemistry, Organic; Periodicals; Electronic journals; 507.78
• DOI: 10.1016/j.carres.2020.108092
• Languages: English
• ISSNs: 0008-6215

Abstract

Abstract: Chemical investigation of the methanol extract of the roots of Lecaniodiscus cupanioides led to the isolation and characterisation of three new sesquiterpene glycosides, named cupanioidesosides A (1), B (2) and C (3), together with one new triterpenoid saponin named lecanioside A (4 ), Their structures were established by extensive analysis of spectroscopic methods including 1D and 2D NMR techniques (COSY, NOESY, TOCSY, HSQC, and HMBC) and HRESIMS. The four new compounds were evaluated for their antiproliferative activity against the Caco-2 cell line (human epithelial cell line). None of the isolated compounds showed positive activity in our assay. Our findings represent a valuable contribution to the chemotaxonomy Lecaniodiscus genus of the subfamily of Sapindoideae of Sapindaceae family, known to be a rich source of farnesol glycosides. Graphical abstract: Image 1 Highlights: Three new sesquiterpene glycosides and one new triterpenoid saponin were isolated from the roots of Lecaniodiscus cupanioides. Their structures were deduced from chemical methods and spectroscopic analysis. None of the isolated compounds showed positive activity in the antiproliferative assay against the Caco-2 cell line.