99mTc-gallic-gold nanoparticles as a new imaging platform for tumor targeting. (October 2020)

• Record Type: Journal Article
• Authors: Sakr, Tamer M.; El-Hashash, M.A.; El-Mohty, A.A.; Essa, Basma M.
• Is Part Of: Applied radiation and isotopes. Volume 164(2020:Oct.)
• Publication Date: 2020-10
• Subjects: Gold nanoparticles -- Gallic acid -- Tumor -- Imaging platform -- Technetium-99m; Radiology -- Periodicals; Radiation -- Industrial applications -- Periodicals; Nuclear chemistry -- Periodicals; Internet resource; Periodical; 660.298
• DOI: 10.1016/j.apradiso.2020.109269
• Languages: English
• ISSNs: 0969-8043

Abstract

Abstract: Early and accurate detection of tumor assists in identifying more effective therapies. Gold nanoparticles (GNPs) were synthesized by green synthesis method using gallic acid (GA) then characterized and labeled with technetium-99m. This new platform was biologically evaluated in both normal and solid tumor bearing mice. The in-vivo study of [ 99m Tc]Tc-gallic-GNPs via both I.V. and I.T injecton showed a high accumulation in tumor site. As a result, [ 99m Tc]Tc-gallic-GNPs can be afforded as a potential nano-platform for tumor imaging. Highlights: Gallic-GNPs were synthesized with core size of 10 nm to be used for as a novel nano-platform for tumor imaging. Gallic-GNPs were radiolabeled with technetium-99m forming [ 99m Tc]Tc-gallic-GNPs complex with a RCY of 81.3%. The in-vivo studies of [ 99m Tc]Tc-gallic-GNPs have a promising results in tumor uptake. The newly synthesized nano-platform affords potential radiopharmaceutical that could be used as tumor imaging probe.