Protein-based functional hybrid bionanomaterials by bottom-up approaches. (August 2020)

• Record Type: Journal Article
• Authors: Beloqui, Ana; Cortajarena, Aitziber L
• Is Part Of: Current opinion in structural biology. Volume 63(2020)
• Page Start: 74
• Page End: 81
• Publication Date: 2020-08
• Subjects: Molecular biology -- Periodicals; 570
• DOI: 10.1016/j.sbi.2020.04.005
• Languages: English
• ISSNs: 0959-440X

Abstract

Highlights: Insitu fabrication of protein-hybrid bionanomaterials leads to new materials with defined and easily tailored architectures 'easily' tailored. Advances in the field aim to achieve protein bionanomaterials with fully encodable properties. Preservation of the nanoscale is of huge relevance for the performance of the bionanomaterials in particular applications. Engineered protein-based bionanomaterials show great promise as future functional systems and vast potential applications. Integrative multidisciplinary approaches are required for the success of these emerging systems. Abstract : This review aims to summarize the last advances on the field of protein engineering towards functional bionanomaterials. Albeit being this an emerging research field, multidisciplinary perspectives in the design of synthetic protein-based hybrid bionanomaterials have resulted in significant progresses. The review covers the definition of bionanomaterials as such and the description of the main methodological approaches currently employed for their assembly. In this context, special emphasis is placed on the fundamental role of protein design. Then, a general overview of the most recent advances related to the fabrication and application of protein-based bionanomaterials in several applications is provided, with special focus on catalysis. Finally, key aspects to be considered by the research community to establish the path for significant future developments in this promising field are discussed.