Consumption of a palatable diet rich in simple sugars during development impairs memory of different degrees of emotionality and changes hippocampal plasticity according to the age of the rats. Issue 5 (15th June 2020)

• Record Type: Journal Article
• Authors: Altermann Torre, Viviane; Machado, Alessandra Gonçalves; de Sá Couto‐Pereira, Natividade; Mar Arcego, Danusa; dos Santos Vieira, Aline; Salerno, Pamela Silva Vitória; dos Santos Garcia, Emily; Lazzaretti, Camilla; Toniazzo, Ana Paula; Nedel, Fernanda; Noschang, Cristie; Schmitz, Felipe; Wyse, Angela T. S.; Dalmaz, Carla; Krolow, Rachel
• Is Part Of: International journal of developmental neuroscience. Issue 80:Issue 5(2020:Aug.)
• Page Start: 354
• Page End: 368
• Publication Date: 2020-06-15
• Subjects: adult period -- hippocampus -- memory -- plasticity -- prepubertal period -- sugar diet; Developmental neurobiology -- Periodicals; Neurology -- Periodicals; Neurologie du développement -- Périodiques; Developmental neurobiology; Periodicals; 612.8
• DOI: 10.1002/jdn.10032
• Languages: English
• ISSNs: 0736-5748

Abstract

Abstract: We investigated the effect of a chronic palatable diet rich in simple sugars on memory of different degrees of emotionality in male adult rats, and on hippocampal plasticity markers in different stages of development. On postnatal day (PND) 21, 45 male Wistar rats were divided in two groups, according to their diet: (1‐Control) receiving standard lab chow or (2‐Palatable Diet) receiving both standard chow plus palatable diet ad libitum. At PND 60, behavioral tests were performed to investigate memory in distinct tasks. Hippocampal plasticity markers were investigated at PND 28 in half of the animals, and after the behavioral tests. Palatable diet consumption induced an impairment in memory, aversive or not, and increased Na +, K + ‐ATPase activity, both at PND 28, and in the adulthood. Synaptophysin, brain‐derived neurotrophic factor (BDNF), and protein kinase B (AKT), and phosphorylated AKT were reduced in the hippocampus at PND 28. However, at PND 75, this diet consumption led to increased hippocampal levels of synaptophysin, spinophilin/neurabin‐II, and decreased BDNF and neuronal nitric oxide synthase. These results showed a strongly association of simple sugars‐rich diet consumption during the development with memory impairments. Plasticity markers are changed, with results that depend on the stage of development evaluated. Abstract : Illustrative figure showing the main effects of consumption of a high palatable diet, rich in simple sugar, from childhood to adulthood, is associated with memory impairments. Analysis of plasticity‐related proteins had different results depending on the stage of development evaluated. At PND 28, palatable diet increased Na +, K + ‐ATPase activity, synaptophysin, brain‐derived neurotrophic factor (BDNF), and protein kinase B (AKT) and phosphorylated AKT were reduced in the hippocampus. However, at PND 75, this diet consumption led to increased hippocampal levels of synaptophysin, spinophilin/neurabin‐II, and decreased BDNF and neuronal nitric oxide synthase.