Hyperacmosins H-J, three new polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum acmosepalum. Issue 6 (2nd June 2020)

• Record Type: Journal Article
• Authors: Wang, Xue; Wang, Jia-Jia; Suo, Xin-Yue; Sun, Hao-Ran; Zhen, Bo; Sun, Hua; Li, Jian-Guang; Ji, Teng-Fei
• Is Part Of: Journal of Asian natural products research. Volume 22:Issue 6(2020)
• Page Start: 521
• Page End: 530
• Publication Date: 2020-06-02
• Subjects: Hypericum acmosepalum -- methylated polycyclic polyprenylated acylphloroglucinols (mPPAPs) -- hepatoprotective; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2020.1739662
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Three new polycyclic polyprenylated acylphloroglucinol derivatives, hyperacmosins H-J (1–3 ), with four known compounds (4–7 ), were isolated from the air-dried aerial parts of Hypericum acmosepalum . Especially, compounds 1 and 2 were identified as methylated polycyclic polyprenylated acylphloroglucinol derivatives (mPPAPs). Their structures were established by NMR, HRESIMS and experimental electronic circular dichroism (ECD) spectra. The hepatoprotective activity of seven compounds were evaluated. Compounds 1 and 5 exhibited hepatoprotective activity against paracetamol-induced HepG2 cell damage.