Impact of biparametric prebiopsy prostate magnetic resonance imaging on the diagnostics of clinically significant prostate cancer in biopsy naïve men. (2nd January 2020)

• Record Type: Journal Article
• Authors: Knaapila, Juha; Autio, Venla; Jambor, Ivan; Ettala, Otto; Verho, Janne; Kiviniemi, Aida; Taimen, Pekka; Perez, Ileana Montoya; Aronen, Hannu J.; Syvänen, Kari T.; Boström, Peter J.
• Is Part Of: Scandinavian journal of urology. Volume 54:Number 1(2020)
• Page Start: 7
• Page End: 13
• Publication Date: 2020-01-02
• Subjects: Clinically significant -- prostate cancer -- biparametric -- magnetic resonance imaging -- MRI -- sensitivity -- diagnostics; Urology -- Periodicals; 616.6
• DOI: 10.1080/21681805.2019.1711161
• Languages: English
• ISSNs: 2168-1805

Abstract

Abstract: Background: The objective of this study was to compare the prevalence of clinically significant prostate cancer (CSPCa) in men with biparametric prebiopsy prostate magnetic resonance imaging (MRI) and lesion-targeted biopsies (TBs) to the group of men without prebiopsy MRI in an initial biopsy session. Methods: The MRI group consists of men enrolled into four prospective clinical trials investigating a biparametric MRI (bpMRI) and TB while the non-MRI group was a retrospective cohort of men collected from an era prior to a clinical use of a prostate MRI. All men had standard biopsies (SBs). In the MRI group, men had additional TBs from potential cancer-suspicious lesions. CSPCa was defined as Gleason score ≥3 + 4 in any biopsy core taken. All the patients were prostate biopsy naïve. Results: The MRI group consists of 507 while the non-MRI group 379 men. Mean age and prostate specific antigen (PSA) level differed significantly ( p < 0.05) between the groups: In the MRI group, 64 years and 7.6 ng/ml, respectively, and in the non-MRI group 68 years and 8.2 ng/ml, respectively. Significantly ( p < 0.05) more CSPCa was diagnosed with initial biopsies in the MRI group (48%) compared to non-MRI group (34%). In men with no CSPCa diagnosed during the initial biopsies, significantly fewer ( p < 0.05) men had upgrading re-biopsies in the MRI group (5%) than in the non-MRI group (19%) during the follow up. Conclusions: Prebiopsy bpMRI with TBs combined with SBs could lead to earlier diagnoses of CSPCa compared with men without prebiopsy prostate MRI used in initial PCa diagnostics.