Freeze-thaw electrospun PVA-dacarbazine nanoparticles: preparation, characterization and anticancer evaluation. Issue 12 (12th August 2020)

• Record Type: Journal Article
• Authors: Steffens Reinhardt, Luiza; Chee, Bor Shin; Cao, Zhi; Jaqueline Moura, Dinara; Nugent, Michael
• Is Part Of: International journal of polymeric materials. Volume 69:Issue 12(2020)
• Page Start: 749
• Page End: 760
• Publication Date: 2020-08-12
• Subjects: Anticancer activity -- Dacarbazine -- electrospinning -- freeze-thaw -- nanoparticles -- polyvinyl alcohol; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2019.1605606
• Languages: English
• ISSNs: 0091-4037

Abstract

Abstract: Dacarbazine (DTIC) is an antitumor agent that has limited clinical applications due to its insolubility, instability and toxicity to normal cells. One possibility to achieve controlled release is PVA-based NPs. This work presents electrospun NPs that combines PVA and DTIC. The results showed that DTIC NPs had mean particle sizes of 458.2 ± 113.6 nm, suggested the presence of DTIC in an amorphous state and showed a burst in vitro drug release followed by constant release. The cytotoxicity evaluation showed that DTIC NPs were effective against glioblastoma cells. This study indicates that the formulated NPs improved DTIC solubility and efficacy. Graphical Abstract: