Alterations of Tear Film and Ocular Surface in Children with Type 1 Diabetes Mellitus. (2nd April 2020)

• Record Type: Journal Article
• Authors: Inanc, Merve; Kiziltoprak, Hasan; Hekimoglu, Rumeysa; Tekin, Kemal; Ozalkak, Servan; Koc, Mustafa; Bayramoglu, Elvan; Zirh, Selim; Yuruker, Sinan; Aycan, Zehra
• Is Part Of: Ocular immunology and inflammation. Volume 28:Number 3(2020)
• Page Start: 362
• Page End: 369
• Publication Date: 2020-04-02
• Subjects: mellitus -- dry eye -- impression cytology -- ocular surface -- tear film; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2019.1571212
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose : To investigate whether diabetes mellitus (DM) affects ocular surface of children with well-controlled type 1 DM. Methods : Sixty-five diabetic patients and 55 age-matched controls enrolled to study. Detailed ocular surface assessment including, ocular surface disease index (OSDI) questionnaire, tear film break-up time (TBUT) analysis, Schirmer test, and conjunctival impression cytologic analysis were performed. Results : Schirmer test and TBUT results were significantly lower in DM group than controls ( p = 0.001, for all). OSDI scores of all participants were within normal range. Impression cytology analysis showed grade 0 changes in all participants and there was no difference between groups for goblet cell density ( p > 0.05). The TBUT results were significantly associated with duration of DM ( r = −0.309, p = 0.036). Conclusion : Diabetic children without symptoms, signs, and definite diagnosis of dry eye still had lower TBUT and Schirmer test results than controls; however, impression cytology analysis was similar in both groups.