Multifunctional Glyco‐Nanosheets to Eradicate Drug‐Resistant Bacteria on Wounds. Issue 10 (21st April 2020)

• Record Type: Journal Article
• Authors: Guo, Zhong; He, Jing‐Xi; Mahadevegowda, Surendra H.; Kho, Shu Hui; Chan‐Park, Mary B.; Liu, Xue‐Wei
• Is Part Of: Advanced healthcare materials. Volume 9:Issue 10(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-04-21
• Subjects: active targeting -- bacteria -- black phosphorus nanosheets -- carbohydrates -- wound healing; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202000265
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Bacterial infection is becoming increasingly lethal with the emergence of antimicrobial resistance, and wounds plagued by such infection are notoriously difficult to heal. Here, the first use of galactose‐black phosphorus nanosheets, (Gal‐BP NSs) as a delivery platform for synergistic antibiotic (kanamycin, Kana) and photothermal treatments against the Gram‐negative microbial strain, Pseudomonas aeruginosa PAO1 (PAO1) is reported. Gal‐BP NSs@Kana can actively target PAO1 and release kanamycin into the bacterial cytoplasm upon near‐infrared laser irradiation. This strategy kills most of the PAO1 through a simultaneous burst of intracellular kanamycin release and photothermal treatment. Comparable antibacterial activities of Gal‐BP NSs@Kana are observed within in vivo mouse models at their wound sites. In addition, this platform accelerates wound healing from PAO1 infection via promotion of neoangiogenesis and collagen production at the wound sites. This work demonstrates the material properties of Gal‐BP NS in fighting bacterial infections and in the treatment of wound healing. Abstract : A new black phosphorus nanosheet‐based delivery platform, galactose‐black phosphorus nanosheets with kanamycin loaded, is prepared for synergistic antibiotic and photothermal treatment of Pseudomonas aeruginosa infection. The formation shows an efficient active targeting to P. aeruginosa PAO1, and bacterial inhibition and killing against P. aeruginosa PAO1 infection in vitro and in vivo.