Recent Progress on the Preparation of Cyclomatrix‐Polyphosphazene Based Micro/Nanospheres and Their Application for Drug Release. Issue 20 (26th May 2020)

• Record Type: Journal Article
• Authors: Mehmood, Sahid; Wang, Li; Yu, Haojie; Haq, Fazal; Fahad, Shah; Bilal‐ul‐Amin, ; Alim Uddin, Md; Haroon, Muhammad
• Is Part Of: ChemistrySelect. Volume 5:Issue 20(2020)
• Page Start: 5939
• Page End: 5958
• Publication Date: 2020-05-26
• Subjects: Cyclomatrix polyphosphazene based micro/nanospheres -- Drug release -- Preparation; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201904844
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Polyphosphazenes (PPZs) are the hybrid polymers composed of nitrogen and phosphorous atoms linked through alternate single and double bond. For the preparation of cyclomatrix polyphosphazene (CMPPZ) based micro/nanospheres, hexachlorocyclotriphosphazene (HCCP) was reacted with monomers containing hydroxyl and amino groups. The cross‐linked structure of CMPPZ is biodegradable and biocompatible in nature. The CMPPZ based micro/nanospheres have potential application in the field of biomedical. In this review article, we have described the different ways for the preparation of CMPPZ based micro/nanospheres and their drug release behavior. The average diameter size and surface morphology of the highly cross‐linked CMPPZ based micro/nanospheres depended on the concentration of both the monomers. This review article also emphasized on the drug release properties of the CMPPZ based micro/nanospheres. Abstract : Preparation of cyclomatrix‐polyphosphazene (CMPPZ) based micro/nanospheres is an imperative field of advanced micro/nanotechnology which is grooming day by day due to progressive research in this area. The highly cross‐linked structure of CMPPZ is biocompatible and biodegradable and used in bio‐medical applications. In this review we have discussed the preparation methods and applications of highly cross‐linked CMPPZ based micro/nanospheres in drug delivery for cancer therapy, which opened a new door for further developments in this field.