C-reactive protein in midlife is associated with depressive symptoms two decades later among men with coronary heart disease. (2nd April 2020)

• Record Type: Journal Article
• Authors: Ravona-Springer, Ramit; Lutski, Miri; Schnaider Beeri, Michal; Goldbourt, Uri; Tanne, David
• Is Part Of: Nordic journal of psychiatry. Volume 74:Number 3(2020)
• Page Start: 226
• Page End: 233
• Publication Date: 2020-04-02
• Subjects: Coronary heart disease -- depression -- elderly -- inflammation; Psychopharmacology -- Periodicals; Psychotherapy -- Periodicals; Psychiatry -- Periodicals; Psychiatry -- Scandinavia -- Periodicals; 616.89
• DOI: 10.1080/08039488.2019.1695284
• Languages: English
• ISSNs: 0803-9488

Abstract

Abstract: Aim: We investigated the relationship between midlife C-reactive protein (CRP) levels in men with coronary heart disease (CHD) and depressive symptoms at old age. CRP levels were measured in a subset of patients with CHD, who previously participated in a secondary prevention trial. Methods: Depressive symptoms were evaluated in survivors of the original cohort 15.0 ± 3 and 19.9 ± 1 years later (T1, n = 463 and T2, n = 314 respectively) using the Geriatric Depression Scale (GDS), 15-item version. Logistic regression was used to estimate ORs and 95%CIs for presence of potentially clinically significant depressive symptoms (GDS ≥5) at T1 and T2. Results: Adjusting for demographic and health-related variables, the OR (95%CI) for GDS ≥5 was 1.23 (0.65–2.33); p = .53 at T1 and 2.36 (1.16–4.83); p = .018 at T2 in the top CRP tertile compared to the others. Similarly, consistently high CRP levels in the top tertile at baseline and 2 years later, were associated with OR of 2.85 (95%CI 1.29–6.30); p = .01 for GDS ≥5 at T2. Conclusions: Presence and persistence of low-grade inflammation in men with CHD during midlife are associated with increased risk of depressive symptoms twenty years later. Among middle aged men with CHD, low-grade inflammation may provide an important added value for prediction of depression in old age.