A rare diketopiperazine glycoside from marine-sourced Streptomyces sp. ZZ446. Issue 7 (2nd April 2020)

• Record Type: Journal Article
• Authors: Chen, Sangluo; Zhang, Di; Chen, Mengxuan; Zhang, Zhizhen; Lian, Xiao-Yuan
• Is Part Of: Natural product research. Volume 34:Issue 7(2020)
• Page Start: 1046
• Page End: 1050
• Publication Date: 2020-04-02
• Subjects: Streptomyces sp. ZZ446 -- diketopiperazine glycoside -- antimicrobial activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1544978
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two diketopiperazines were isolated from a culture of the marine-derived actinomycete Streptomyces sp. ZZ446. Their structures were elucidated as maculosin (1 ) and maculosin- O - α -L -rhamnopyranoside (2 ) based on their NMR and HRESIMS data, specific rotation, and chemical degradation. Maculosin- O - α -L -rhamnopyranoside (2 ) is a new diketopiperazine glycoside, a structural class not reported previously from the natural sources. Both compounds showed antimicrobial activity against methicillin-resistant Staphylococcus aureus, Escherichia coli, and Candida albicans with MIC values in a range from 26.0 to 37.0 μg/mL.