The human microbiome in health and disease: hype or hope. Issue 2 (4th March 2019)

• Record Type: Journal Article
• Authors: Falony, Gwen; Vandeputte, Doris; Caenepeel, Clara; Vieira-Silva, Sara; Daryoush, Tanine; Vermeire, Séverine; Raes, Jeroen
• Is Part Of: Acta clinica belgica. Volume 74:Issue 2(2019)
• Page Start: 53
• Page End: 64
• Publication Date: 2019-03-04
• Subjects: Microbiota variation -- quantitative microbiome profiling -- microbiome covariates -- transit time -- microbiota modulation strategies; Clinical medicine -- Periodicals; Diagnosis, Laboratory -- Periodicals; 616.005
• DOI: 10.1080/17843286.2019.1583782
• Languages: English
• ISSNs: 1784-3286

Abstract

ABSTRACT: Objectives : The prognostic, diagnostic, and therapeutic potential of the human gut microbiota is widely recognised. However, translation of microbiome findings to clinical practice is challenging. Here, we discuss current knowledge and applications in the field. Methods : We revisit some recent advances in the field of faecal microbiome analyses with a focus on covariate analyses and ecological interpretation. Results : Population-level characterization of gut microbiota variation among healthy volunteers has allowed identifying microbiome covariates required for clinical studies. Currently, microbiome research is moving from relative to quantitative approaches that will shed a new light on microbiota–host interactions in health and disease. Conclusions : Covariate characterization and technical advances increase reproducibility of microbiome research. Targeted in vitro / in vivo intervention studies will accelerate clinical implementation of microbiota findings.