Synergistic Pd/Cu Catalysis in Organic Synthesis. Issue 22 (21st February 2020)

• Record Type: Journal Article
• Authors: Wu, Yue; Huo, Xiaohong; Zhang, Wanbin
• Is Part Of: Chemistry. Volume 26:Issue 22(2020)
• Page Start: 4895
• Page End: 4916
• Publication Date: 2020-02-21
• Subjects: bimetallic catalysis -- cross-coupling -- Sonogashira reaction -- stereodivergent synthesis -- synergistic Pd/Cu catalysis; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201904495
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Synergistic Pd/Cu catalysis has been utilized in the Sonogashira reaction since 1975. However, this strategy has not received much attention from the organic chemist community until recently. Synergistic Pd/Cu catalysis is becoming a proficient method for the development of catalytic reactions, including several new and efficient cross‐coupling reactions. Additionally, several challenging asymmetric reactions, including stereodivergent synthesis, have been discovered by the combined use of a chiral metal catalyst and a second achiral metal catalyst or two chiral metal catalysts. This review provides an overview of this field, with the aims of highlighting both the development of synergistic Pd/Cu catalysis in organic synthesis and the reaction mechanisms involved in this research area. Abstract : Synergistic Pd/Cu catalysis is becoming a proficient method for the development of catalytic reactions, including several new and efficient cross‐coupling reactions. Additionally, several challenging asymmetric reactions, including stereodivergent synthesis, have been discovered by the combined use of a chiral metal catalyst and a second achiral metal catalyst or two chiral metal catalysts.