Aqueous fullerene C60 solution suppresses herpes simplex virus and cytomegalovirus infections. Issue 6 (2nd June 2020)

• Record Type: Journal Article
• Authors: Klimova, Regina; Andreev, Sergey; Momotyuk, Ekaterina; Demidova, Natalia; Fedorova, Natalia; Chernoryzh, Yana; Yurlov, Kirill; Turetskiy, Evgeny; Baraboshkina, Elena; Shershakova, Nadezhda; Simonov, Ruslan; Kushch, Alla; Khaitov, Musa; Gintsburg, Alexander
• Is Part Of: Fullerenes, nanotubes and carbon nanostructures. Volume 28:Issue 6(2020)
• Page Start: 487
• Page End: 499
• Publication Date: 2020-06-02
• Subjects: Aqueous C60 dispersion -- C60 adducts -- Herpes simplex virus -- Human cytomegalovirus -- antiviral activity; Fullerenes -- Periodicals; Nanotubes -- Periodicals; Nanostructures -- Periodicals; 546.6812
• DOI: 10.1080/1536383X.2019.1706495
• Languages: English
• ISSNs: 1536-383X

Abstract

Abstract: Fullerene C60 is known as a promising therapeutic agent due to its antioxidant, anti-inflammatory and other properties, along with the lack of noticeable toxicity. In this article, we describe antiviral properties of aqueous fullerene C60 dispersion (ndC60 ) produced by biocompatible diafiltration technology and C60 amino derivatives against Herpes simplex virus type 1 (HSV-1) and Human cytomegalovirus (HCMV) infections. Their activity in vitro was evaluated by a plaque reduction assay using Vero and HF cells in pre- and post-treatment modes. Therapeutic efficacy of dnC60 and C60 derivatives was studied in DBA mice using cutaneous model of HSV-1 infection. Data obtained indicated low cytotoxicity of all used compounds for both cell lines (CC50 > 1 mg/ml). The antiviral activity of dnC60 in most tests exceeded the activity of both C60 amino adducts and acyclovir (ACV), and it demonstrated significant therapeutic effect against HSV-1 skin infection in mice.