Role of microRNAs in Staphylococcus aureus infection: Potential biomarkers and mechanism. Issue 9 (9th June 2020)

• Record Type: Journal Article
• Authors: Mirzaei, Rasoul; Mohammadzadeh, Rokhsareh; Mirzaei, Hamed; Sholeh, Mohammad; Karampoor, Sajad; Abdi, Milad; Alikhani, Mohammad Yousef; Kazemi, Sima; Ahmadyousefi, Yaghoub; Jalalifar, Saba; Yousefimashouf, Rasoul
• Is Part Of: IUBMB life. Volume 72:Issue 9(2020)
• Page Start: 1856
• Page End: 1869
• Publication Date: 2020-06-09
• Subjects: immune response: Biomarker -- infection -- microRNAs -- Staphylococcus aureus; Biochemistry -- Periodicals; Molecular biology -- Periodicals; 572.8
• DOI: 10.1002/iub.2325
• Languages: English
• ISSNs: 1521-6543

Abstract

Abstract: Staphylococcus aureus is known as a common pathogen that colonizes 30% of healthy humans. Additionally, this bacterium can cause a number of serious infections, that is, endocarditis, bacteremia, pneumonia, wound, skin infections, and tissue abscesses. A variety of cellular and molecular pathways and targets are involved in response against S. aureus . Among them, microRNAs (miRNAs) have crucial roles in response against S. aureus . In this regard, it has been shown that these molecules exert their regulatory roles via modulating a wide range of events, such as inflammatory reactions, host innate, and adaptive immunity. Current works have provided insight into the crucial involvement of miRNAs in immune defense toward Staphylococcal infections. Herein, we highlighted the current findings on the deregulation of different miRNAs in S. aureus ‐infected cells . Moreover, we summarized the mechanisms and targets of miRNAs in S. aureus infections.