Hybrid chitosan/amniotic membrane-based hydrogels for articular cartilage tissue engineering application. Issue 15 (12th October 2020)

• Record Type: Journal Article
• Authors: Toniato, Tatiane Venturott; Stocco, Thiago Domingues; Martins, Danilo dos Santos; Santanna, Luciana Barros; Tim, Carla Roberta; Marciano, Fernanda Roberta; Silva-Filho, Edson Cavalcanti; Campana-Filho, Sérgio Paulo; Lobo, Anderson de Oliveira
• Is Part Of: International journal of polymeric materials. Volume 69:Issue 15(2020)
• Page Start: 961
• Page End: 970
• Publication Date: 2020-10-12
• Subjects: Amniotic membrane -- cartilaginous tissue -- chitosan -- hydrogels -- tissue engineering; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2019.1636249
• Languages: English
• ISSNs: 0091-4037

Abstract

Abstract: A hybrid hydrogel combining collagen and chitosan (Ch) and human amniotic membranes (AM) were produced. To produce hybrid hydrogels, a fixed concentration of chitosan (2%) was used, adding AM as a booster at the concentrations of 2.5, 5.0. and 10.0% ( w/w ). DSC curves showed the denaturation of collagen. The swelling capacity of hydrogels ranged between 333 ± 19% and 368 ± 28%. The groups Ch-1.0 mg/mL and Ch-2.0 mg/mL had an elastic modulus 27% higher than the other groups. Graphical Abstract: