New oral liposomal vitamin C formulation: properties and bioavailability. (2nd July 2020)

• Record Type: Journal Article
• Authors: Łukawski, Maciej; Dałek, Paulina; Borowik, Tomasz; Foryś, Aleksander; Langner, Marek; Witkiewicz, Wojciech; Przybyło, Magdalena
• Is Part Of: Journal of liposome research. Volume 30:Number 3(2020)
• Page Start: 227
• Page End: 234
• Publication Date: 2020-07-02
• Subjects: Liposome -- vitamin C -- efficacy -- bioavailability -- stability; Liposomes -- Periodicals; Liposomes -- Periodicals; 575.57
• DOI: 10.1080/08982104.2019.1630642
• Languages: English
• ISSNs: 0898-2104

Abstract

Abstract: Vitamin C is the exogenous compound necessary for a variety of metabolic processes; therefore, the efficient delivery is critical for the maintenance of body homeostasis. Vitamin C pharmacokinetics and low quantities in processed foodstuff, necessitates its continuous supplementation. In the paper, we present the new liposomal formulation of vitamin C free of harmful organic solvents. The formulation was quantitatively characterized with respect to its chemically composition and nano-structuring. The vitamin C accessibility to cells from the formulation was evaluated using evidence derived from experiments performed on cell cultures. Finally, the enhanced bioavailability of vitamin C from the formulation was demonstrated in the medical experiment.