Prevalence of High-risk Nonavalent Vaccine-type Human Papillomavirus Infection Among Unvaccinated, Sexually Active Asian Female Adolescents With and Without Perinatally Acquired HIV Infection. Issue 7 (July 2020)

• Record Type: Journal Article
• Authors: Sricharoenchai, Sirintip; Kerr, Stephen J.; Gatechompol, Sivaporn; Hansudewechakul, Rawiwan; Dang, Hanh Le Dung; Tran, Dan Ngoc Hanh; Teeratakulpisarn, Nipat; Chalermchockcharoenkit, Amphan; Achalapong, Jullapong; Teeraananchai, Sirinya; Singtoroj, Thida; Phanuphak, Nittaya; Sohn, Annette H.; Chokephaibulkit, Kulkanya
• Is Part Of: Pediatric infectious disease journal. Volume 39:Issue 7(2020)
• Publication Date: 2020-07
• Subjects: papillomavirus vaccine -- papillomavirus infection -- HIV -- adolescent -- young adult; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000002659
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : Background: We studied the prevalence of 7, high-risk human papillomavirus (HPV) types in the nonavalent vaccine (HRVT-7: HPV 16, 18, 31, 33, 45, 52, 58) among vaccine-naïve, sexually active Asian female adolescents with and without perinatally acquired HIV infection (PHIV). Methods: PHIV female adolescents 12–24 years of age and HIV-uninfected controls matched by age and number of lifetime sex partners were enrolled in a 3-year observational cohort study in Thailand and Vietnam. Samples from the oral cavity, anus, cervix and vagina were collected for HRVT-7 HPV genotyping, and serum collected for HPV 16 and 18 antibody testing. Baseline data were analyzed using multivariable logistic regression. Results: We included 93 PHIV (median CD4 593 cells/mm 3, 62% with HIV RNA suppression) and 99 HIV-uninfected adolescents (median lifetime sex partners 2). The overall prevalence of HRVT-7 infection was 53% in PHIV and 49% in HIV-uninfected adolescents ( P = 0.66). Cervical HRVT-7 DNA was detected more frequently in PHIV than HIV-uninfected adolescents (37% vs. 23%, P = 0.04). Overall, more lifetime partners [≥3 vs. 1; odds ratio (OR) 2.99 (1.38–6.51), P = 0.02] and having other sexually transmitted infections [OR 3.30 (1.51–7.21), P = 0.003] increased the risk of HRVT-7 infection and/or positive HPV 16/18 antibodies; while detectable HIV RNA [OR 2.78 (1.05–7.36), P = 0.04] increased the risk among PHIV adolescents. Conclusions: Half of sexually active Asian female adolescents, regardless of HIV infection, had already acquired HRVT-7 infection. This underscores the need for earlier access to HPV vaccine in the region. Abstract : Supplemental Digital Content is available in the text.