Antihyperthermic treatment decreases perihematomal hypodensity. (21st April 2020)

• Record Type: Journal Article
• Authors: Hervella, Pablo; Rodríguez-Yáñez, Manuel; Pumar, José Manuel; Ávila-Gómez, Paulo; da Silva-Candal, Andrés; López-Loureiro, Ignacio; Rodríguez-Maqueda, Elena; Correa-Paz, Clara; Castillo, José; Sobrino, Tomás; Campos, Francisco; Iglesias-Rey, Ramón
• Is Part Of: Neurology. Volume 94:Number 16(2020)
• Publication Date: 2020-04-21
• Subjects: Neurology -- Periodicals; Neurology -- Periodicals; Neurologie -- Périodiques; 616.8
• DOI: 10.1212/WNL.0000000000009288
• Languages: English
• ISSNs: 0028-3878

Abstract

Abstract : Objective: To investigate the effect on perihematomal hypodensity and outcome of a decrease in body temperature in the first 24 hours in patients with intracerebral hemorrhage (ICH). Methods: In this retrospective study on a prospectively registered database, among the 1, 100 patients, 795 met all the inclusion criteria. Temperature variations in the first 24 hours and perihematomal hypodensity (PHHD) were recorded. Patients ≥37.5°C were treated with antihyperthermic drugs for at least 48 hours. The main objective was to determine the association among temperature variation, PHHD, and outcome at 3 months. Results: The decrease in temperature in the first 24 hours increased the possibility of good outcome 11-fold. Temperature decrease, lower PHHD volume, and a good outcome were observed in 31.8% of the patients who received antihyperthermic treatment. Conclusion: The administration of early antihyperthermic treatment in patients with spontaneous ICH with a basal axillary temperature ≥37.5°C resulted in good outcome in a third of the treated patients.