The Treatment of Acute Rheumatic Fever: Novel Use of Hydroxychloroquine. Issue 7 (July 2020)

• Record Type: Journal Article
• Authors: Wilson, Nigel J.; Concannon, Anthony; Malcolm, John; Davidakova, Sarka; Martin, William John; Webb, Rachel; Moreland, Nicole J.
• Is Part Of: Pediatric infectious disease journal. Volume 39:Issue 7(2020)
• Publication Date: 2020-07
• Subjects: rheumatic fever -- rheumatic heart disease -- hydroxychloroquine -- corticosteroids -- GM-CSF; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000002647
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : Hydroxychloroquine (HCQ) suppresses an interleukin-1β-granulocyte-macrophage colony-stimulating factor cytokine axis, reported to be dysregulated in peripheral blood mononuclear cells of acute rheumatic fever patients ex vivo . We describe HCQ treatment for 2 patients with rheumatic carditis and a protracted inflammatory course. HCQ was associated with control of inflammatory markers, control of pericarditis in first patient and stabilization of progressive carditis in the second patient.