Variability of Steady State Oral Baclofen Prescribing Practices in Pediatric Patients With Cerebral Palsy. (May 2020)

• Record Type: Journal Article
• Authors: McLaughlin, Matthew J.; Ratnasingam, Denesh; McGhee, Emily
• Is Part Of: American journal of physical medicine & rehabilitation. Volume 99:Number 5(2020)
• Publication Date: 2020-05
• Subjects: Cerebral Palsy -- Baclofen -- Pediatrics -- Precision Medicine; Rehabilitation -- Periodicals; Medicine, Physical -- Periodicals; 617.062
• DOI: 10.1097/PHM.0000000000001334
• Languages: English
• ISSNs: 0894-9115

Abstract

Abstract : Abstract: The aim of the study was to identify oral baclofen dosing variability at steady state based on weight and Gross Motor Function Classification System level using a retrospective cross-sectional study design. The medical records of 500 pediatric aged patients (age 1–21 yrs) were reviewed to obtain 144 pediatric patients who met inclusion criteria. One-way analysis of variance tests revealed increasing mean doses in baclofen (in milligram per kilogram) with higher Gross Motor Function Classification System levels ( P = 0.001). Post hoc Tukey analysis showed patients with higher ambulatory ability (Gross Motor Function Classification System I–II) received a lower total daily dosage than did patients with less ambulatory ability (Gross Motor Function Classification System III–V). A moderate correlation was observed with increasing oral baclofen dose as weight increased ( r = 0.43, P < 0.0001). Because of the variability in dosing between Gross Motor Function Classification System levels, prescribing oral baclofen for pediatric patients with cerebral palsy may not follow the traditional model of weight-based dosing seen in other pediatric conditions. Abstract : Supplemental digital content is available in the text.