Clearance of Immunodeficiency-associated Vaccine-derived Poliovirus Infection With Pocapavir. Issue 5 (May 2020)

• Record Type: Journal Article
• Authors: Copelyn, Julie; Hincks, Jeffrey R.; Wilmshurst, Jo M.; Petersen, Wonita; Howard, Wayne; Jallow, Sabelle; Moonsamy, Shelina; Seakamela, Lerato; Suchard, Melinda; Collett, Marc S.; Eley, Brian
• Is Part Of: Pediatric infectious disease journal. Volume 39:Issue 5(2020)
• Publication Date: 2020-05
• Subjects: pocapavir -- immunodeficiency-associated vaccine-derived poliovirus -- poliovirus -- primary immunodeficiency; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000002584
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : Pocapavir exhibits antiviral activity against both polio and nonpolio enteroviruses. There is limited experience of the use of this investigational drug in young children with enteroviral infection. We describe the successful clearance of prolonged immunodeficiency-associated vaccine-derived type 3 poliovirus infection by pocapavir in an infant with underlying X-linked agammaglobulinemia.