Influenza or Meningococcal Immunization During Pregnancy and Mortality in Women and Infants: A Pooled Analysis of Randomized Controlled Trials. Issue 7 (July 2020)

• Record Type: Journal Article
• Authors: Clark, Dayna R.; Omer, Saad B.; Tapia, Milagritos D.; Nunes, Marta C.; Cutland, Clare L.; Tielsch, James M.; Wairagkar, Niteen; Madhi, Shabir A.
• Is Part Of: Pediatric infectious disease journal. Volume 39:Issue 7(2020)
• Publication Date: 2020-07
• Subjects: maternal immunization -- influenza -- meningococcal -- vaccine -- randomized controlled trial; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000002629
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : This analysis includes pooled data from 2 placebo-controlled maternal influenza immunization trials, with a separate analysis on a meningococcal conjugate vaccine-controlled maternal influenza immunization trial. Maternal influenza immunization was not associated with infant or maternal all-cause mortality in placebo-controlled trials. In the meningococcal conjugate vaccine-controlled trial, there were fewer deaths during low or any influenza circulation weeks among infants whose mothers received meningococcal conjugate vaccine. ClinicalTrials.gov identifiers: NCT01430689, NCT01034254 and NCT02465190.