Favourable modulation of osteoblast cellular activity on Cu-containing austenitic stainless steel and comparison with the Cu-free counterpart. (6th June 2020)

• Record Type: Journal Article
• Authors: Gong, N.; Misra, R.D.K.
• Is Part Of: Materials technology. Volume 35:Number 7(2020)
• Page Start: 411
• Page End: 420
• Publication Date: 2020-06-06
• Subjects: Copper-containing austenitic stainless steel -- osteoblast functions -- proteins; Materials -- Periodicals; Materials science -- Periodicals; Materials -- Technological innovations -- Periodicals; 620.1105
• DOI: 10.1080/10667857.2019.1690201
• Languages: English
• ISSNs: 1066-7857

Abstract

ABSTRACT: In the present study, we describe the favorable modulation of osteoblast functions on Cu-containing austenitic stainless steel in comparison to the Cu-free steel. A series of biological experiments were conducted to understand the determining role of Cu in stainless steel on cellular activity. The study clearly demonstrated that cell attachment, proliferation, and cell-material interactions were significantly enhanced in the presence of Cu. The % area covered by cells increased from 13.4% to 17.8% on Cu-free steel and 17.7% to 25.2% on Cu-containing steel after 2 h and 24 h of incubation, respectively. Similarly, the cell density increased from ~3845 cells/cm2 to ~5481 cells/cm2 on Cu-free steel and ~4990 cells/cm2 to ~8590 cells/cm2 on Cu-containing steel after 2 h and 24 h of incubation, respectively. It is underscored that copper can be added to biomedical alloys from the perspective of cellular functions.