Deficits in Bone Architecture and Strength in Children Living With HIV on Antiretroviral Therapy. (1st May 2020)

• Record Type: Journal Article
• Authors: Shiau, Stephanie; Yin, Michael T.; Strehlau, Renate; Burke, Megan; Patel, Faeezah; Kuhn, Louise; Coovadia, Ashraf; Norris, Shane A.; Arpadi, Stephen M.
• Is Part Of: Journal of acquired immune deficiency syndromes. Volume 84:Number 1(2020)
• Publication Date: 2020-05-01
• Subjects: bone -- lopinavir -- efavirenz -- bone density -- pediatrics; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome -- Periodicals; AIDS (Disease); Periodicals; 616.9792005
• DOI: 10.1097/QAI.0000000000002309
• Languages: English
• ISSNs: 1525-4135

Abstract

Abstract : Background: Reduced bone mineral mass by dual x-ray absorptiometry is reported in children living with HIV (CLWH), but few studies of bone microarchitecture, particularly in sub-Saharan Africa, have been conducted. Here, we compare bone architecture and strength in black South African CLWH and uninfected control children by peripheral quantitative computed tomography (pQCT). Setting and Methods: One hundred seventy-two CLWH on antiretroviral therapy (ART) and 98 controls in the CHANGES Bone Study in Johannesburg, South Africa received pQCT scans of the radius and tibia. Measurements included trabecular and cortical volumetric bone mineral density (vBMD) and bone strength, estimated by the polar strength strain index (SSI), a validated measure of fracture risk. Results: CLWH (51% boys) and controls (63% boys) were an average of age 10.4 years. Mean ART duration for CLWH was 9.5 years, with 70.9% on an efavirenz-based, 28.5% on a lopinavir/ritonavir-based, and 1 child on an atazanavir/ritonavir-based regimen. Male CLWH had lower trabecular vBMD at the radius than controls after adjustment for age, radial length, and Tanner stage (β = −17.3, standard error = 7.2, P = 0.018). Bone strength by polar SSI was lower in CLWH than controls (778 vs. 972 mm 3, P < 0.01). CLWH on an LPV/r-based regimen had lower trabecular vBMD (199 vs. 222 mg/cm 3, P < 0.001) and cortical vBMD (1074 vs. 1093 mg/cm 3, P = 0.004) than those on an efavirenz-based regimen. No difference in bone strength by polar SSI was observed between treatment groups. Conclusion: CLWH initiated on ART early in life with well-controlled HIV have deficits in bone architecture and reductions in bone strength as detected by pQCT.