Examining the Relationship between a Verbal Incidental Learning Measure from the WAIS-IV and Neuroimaging Biomarkers for Alzheimer's Pathology. Issue 3 (2nd April 2020)

• Record Type: Journal Article
• Authors: Hammers, Dustin B.; Kucera, Amanda; Spencer, Robert J.; Abildskov, Tracy J.; Archibald, Zane G.; Hoffman, John M.; Wilde, Elizabeth A.
• Is Part Of: Developmental neuropsychology. Volume 45:Issue 3(2020)
• Page Start: 95
• Page End: 109
• Publication Date: 2020-04-02
• Subjects: Neuropsychology -- Periodicals; 612.8
• DOI: 10.1080/87565641.2020.1762602
• Languages: English
• ISSNs: 8756-5641

Abstract

ABSTRACT: Convergent validation of a verbal incidental learning (IL) task from the WAIS-IV using neuroimaging biomarkers is warranted to understand its sensitivity to Alzheimer's disease (AD) pathology. Fifty-five memory clinic patients aged 59 to 87 years received neuropsychological assessment, and measures of IL and quantitative brain imaging. Worse IL-Total Score and IL-Similarities performances were significantly associated with smaller hemispheric hippocampal volumes. IL measures were not significantly correlated with cerebral β-amyloid burden, though a trend was present and effect sizes were mild. These hippocampal volume results suggest that this IL task may be sensitive to AD pathology along the AD continuum.