Contact Dermatitis Associated With Nail Care Products: Retrospective Analysis of North American Contact Dermatitis Group Data, 2001–2016. Issue 3 (May 2020)

• Record Type: Journal Article
• Authors: Warshaw, Erin M.; Voller, Lindsey M.; Silverberg, Jonathan I.; DeKoven, Joel G.; Atwater, Amber R.; Maibach, Howard I.; Reeder, Margo J.; Sasseville, Denis; Belsito, Donald V.; DeLeo, Vincent A.; Fransway, Anthony F.; Fowler, Joseph F.; Taylor, James S.; Pratt, Melanie D.; Mathias, Toby; Marks, James G.; Zug, Kathryn A.; Zirwas, Matthew J.
• Is Part Of: Dermatitis. Volume 31:Issue 3(2020)
• Publication Date: 2020-05
• Subjects: Skin -- Inflammation -- Periodicals; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; Dermatitis, Contact -- Periodicals; Dermatitis, Atopic -- Periodicals; Dermatitis, Occupational -- Periodicals; Drug Eruptions -- Periodicals; 616.51
• DOI: 10.1097/DER.0000000000000583
• Languages: English
• ISSNs: 1710-3568

Abstract

Abstract : Background: Ingredients in nail care products may lead to allergic and/or irritant contact dermatitis. Objective: The aims of this study were to determine frequency of contact dermatitis associated with nail care products, characterize associated body sites, and describe causative allergens. Methods: A retrospective analysis was conducted with the North American Contact Dermatitis Group data between 2001 and 2016. Results: Of the 38, 775 patients tested, 769 (2.0%) had: 1) more than 1 allergic patch test reaction associated with a nail care product (n = 746), 2) irritant contact dermatitis associated with a nail care product (n = 14), or 3) both (n = 9). Primary body sites included the face (43.0%) and hands (27.6%). The top 5 allergens were (2-hydroxyethyl methacrylate (273/482, 56.6%), methyl methacrylate (210/755, 27.8%), ethyl acrylate (190/755, 25.2%), ethyl-2-cyanoacrylate (12/175, 6.9%) and tosylamide (273/755, 36.2%). Frequency of allergy to 2-hydroxyethyl methacrylate ( P = 0.0069) and ethyl acrylate ( P = 0.0024) significantly increased over the study period, whereas allergy secondary to tosylamide significantly decreased ( P < 0.0001). Conclusions: As long-lasting nail techniques become widespread, the prevalence of contact dermatitis to nail care products is expected to increase. Almost one-fifth of nail care product–associated allergens would have been missed without additional screening allergens beyond the North American Contact Dermatitis Group series, underscoring the need for testing to a broad array of allergens.