68Ga-NEB PET/CT can be a new method for diagnosing chylous fistula: Case reports of a rare complication after breast cancer surgery. Issue 29 (17th July 2020)

• Record Type: Journal Article
• Authors: Peng, Li; Zhao, Jialin; Mao, Feng; Sun, Qiang
• Other Names: Saranathan. Maya section editor.
• Is Part Of: Medicine. Volume 99:Issue 29(2020)
• Publication Date: 2020-07-17
• Subjects: 68Ga-NEB PET/CT -- breast cancer surgery -- chylous fistula -- rare complication; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000021201
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Rationale: We hypothesize that with the determination of lymph fistula location 3-dimensionally, application of appropriate pressure would promote fistula healing, and a secondary surgery may be avoided. 68 Ga-labeled 1, 4, 7-triazacyclononane-N, N', N"-triacetic acid (NOTA) conjugated with truncated Evan blue (NEB) forms a complex with serum albumin in the interstitial fluid after it is locally injected and allows rapid visualization of the lymphatic system. Patient concerns: A 44-year-old woman had a chief complaint of left nipple discharge. A 38-year-old woman came to the hospital after sensing a right breast mass. Diagnoses: The 2 patients were diagnosed with chylous fistula after breast cancer surgery based on the findings of a novel method, 68 Ga-NOTA-Evans Blue (NEB) positron emission tomography/computed tomography. Interventions: We successfully obtained clear images to locate the fistula using 68 Ga-NEB positron emission tomography/computed tomography (PET/CT) for both patients. The lymphatic vessels and lymph nodes could be clearly visualized owing to the 68 Ga-NEB activity during PET/CT. Outcomes: Three-dimensional positioning to locate the fistula could direct the application of the pressure dressing and reduce drainage markedly. Lessons: 68 Ga-NEB PET/CT may be a new method for diagnosing chylous fistula and providing guidance for treatment.