HLA association in MOG-IgG– and AQP4-IgG–related disorders of the CNS in the Dutch population. Issue 3 (May 2020)

• Record Type: Journal Article
• Authors: Bruijstens, Arlette L.; Wong, Yu Yi M.; van Pelt, Daniëlle E.; van der Linden, Pieter J.E.; Haasnoot, Geert W.; Hintzen, Rogier Q.; Claas, Frans H.J.; Neuteboom, Rinze F.; Wokke, Beatrijs H.A.
• Is Part Of: Neurology. Volume 7:Issue 3(2020)
• Publication Date: 2020-05
• Subjects: Neuroimmunology -- Periodicals; Neurology -- Periodicals; 616.8
• DOI: 10.1212/NXI.0000000000000702
• Languages: English
• ISSNs: 2332-7812

Abstract

Abstract : Objective: To investigate the possible human leukocyte antigen (HLA) association of both myelin oligodendrocyte glycoprotein (MOG-IgG)-associated diseases (MOGAD) and aquaporin-4 antibody (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (NMOSDs) in the Dutch population with European ancestry to clarify similarities or differences in the immunogenetic background of both diseases. Methods: Blood samples from patients in the Dutch national MS/NMOSD expert clinic were tested for MOG-IgG and AQP4-IgG using a cell-based assay. HLA Class I and II genotyping was performed in 43 MOG-IgG–seropositive and 42 AQP4-IgG–seropositive Dutch patients with European ancestry and compared with those of 5, 604 Dutch healthy blood donors. Results: No significant HLA association was found in MOG-IgG–seropositive patients. The AQP4-IgG–seropositive patients had a significant higher frequency of HLA-A*01 (61.9% vs 33.7%, OR 3.16, 95% CI, 1.707–5.863, p after correction [ p c] = 0.0045), HLA-B*08 (61.9% vs 25.6%, OR 4.66, 95% CI, 2.513–8.643, p c < 0.0001), and HLA-DRB1*03 (51.2% vs 27.6%, OR 2.75, 95% CI, 1.495–5.042, p c = 0.0199) compared with controls. Conclusions: The present study demonstrates differences in the immunogenetic background of MOGAD and AQP4-IgG–positive NMOSD. The strong positive association with HLA-A*01, -B*08, and -DRB1*03 is suggestive of a role of this haplotype in the etiology of AQP4-IgG–positive NMOSD in patients with European ancestry, whereas in MOGAD no evidence was found for any HLA association in these disorders.