Comparison of laparoscopic cholecystectomy with and without abdominal drainage in patients with non-complicated benign gallbladder disease: A protocol for systematic review and meta analysis. Issue 20 (15th May 2020)

• Record Type: Journal Article
• Authors: Yang, Jia; Liu, Yang; Yan, Peijing; Tian, Hongwei; Jing, Wutang; Si, Moubo; Yang, Kehu; Guo, Tiankang
• Other Names: Kantarçeken. Bülent section editor.
• Is Part Of: Medicine. Volume 99:Issue 20(2020)
• Publication Date: 2020-05-15
• Subjects: drain -- laparoscopic cholecystectomy -- meta-analysis; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000020070
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Objective: To evaluate whether conventional postoperative drainage is more effective than not providing drainage in patients with non-complicated benign gallbladder disease following laparoscopic cholecystectomy (LC). Methods: A search of the electronic databases MEDLINE, EMBASE, Web of science, Cochrane Library, and Chinese Biomedical Database (CBM) was conducted for randomized controlled trials (RCTs) reporting outcomes of LC surgery with and without an abdominal drain. Results: Twenty-one RCTs involving 3246 patients (1666 with drains vs 1580 without) were included in the meta-analysis. There were no statistically significant differences in the rates of incidence of intra-abdominal fluid (RR: 1.10; 95% CI: 0.81–1.49; P = .54) or post-surgical mortality (RR: 0.44; 95% CI: 0.04–4.72; P = .50) between the two groups. Abdominal drains did not reduce the overall incidence of nausea and vomiting (RR: 1.16; 95% CI: 0.95–1.42; P = .15) or shoulder tip pain (RR: 1.03; 95% CI: 0.76–1.38; P = .86). The abdominal drain group displayed significantly higher pain scores (MD: 1.07; 95% CI: 0.69–1.46; P < .001) than the non-drainage patients. Abdominal drains prolonged the duration of the surgical procedure (MD: 5.69 min; 95% CI: 2.51–8.87; P = .005) and postoperative hospital stay (MD: 0.47 day; 95% CI: 0.14–0.80; P = .005). Wound infection was found to be associated with the use of abdominal drains (RR: 1.97; 95% CI: 1.11–3.47; P = .02). Conclusions: Currently, there is no evidence to support the use of routine drainage after LC in non-complicated benign gallbladder disease. Further well-designed randomized clinical trials are required to confirm this finding. Abstract : Supplemental Digital Content is available in the text