Assessment of pain and structure after an intra-articular injection of adalimumab in osteoarthritis of the knee: A case report. Issue 28 (10th July 2020)

• Record Type: Journal Article
• Authors: Vasudeva, Abhimanyu; Yadav, Shiv Lal; Nanda, Srishti; Sahu, Samantak
• Other Names: Saranathan. Maya section editor.
• Is Part Of: Medicine. Volume 99:Issue 28(2020)
• Publication Date: 2020-07-10
• Subjects: adalimumab -- knee -- osteoarthritis -- pain; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000021131
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Introduction: Tumor necrosis factor alpha (TNF-α) mediated inflammation has been implicated, in knee osteoarthritis, despite being a predominantly degenerative condition. Patient Concerns: A 56-year old female, a case of left knee pain not responding to conventional conservative strategies. Diagnosis: A diagnosis of primary osteoarthritis of the left knee, grade 3 osteoarthritis as per the Kellgren-Lawrence Scale was established. Interventions: She was administered an intra-articular injection of 10 mg of Adalimumab, a commonly used anti-TNF agent. Outcomes: The patient was evaluated at baseline, 1 month, 3 months, and at 6 months. There was a marked improvement in pain intensity (visual analog scale) and quality of life, despite no objective change on the parameters seen on ultrasound of the knee. Conclusion: Injection of adalimumab via the intra-articular route into the knee joint in primary osteoarthritis yields promising results.