Ictal quantitative surface electromyography correlates with postictal EEG suppression. (16th June 2020)

• Record Type: Journal Article
• Authors: Arbune, Anca A.; Conradsen, Isa; Cardenas, Damon P.; Whitmire, Luke E.; Voyles, Shannon R.; Wolf, Peter; Lhatoo, Samden; Ryvlin, Philippe; Beniczky, Sándor
• Is Part Of: Neurology. Volume 94:Number 24(2020)
• Publication Date: 2020-06-16
• Subjects: Neurology -- Periodicals; Neurology -- Periodicals; Neurologie -- Périodiques; 616.8
• DOI: 10.1212/WNL.0000000000009492
• Languages: English
• ISSNs: 0028-3878

Abstract

Abstract : Objective: To test the hypothesis that neurophysiologic biomarkers of muscle activation during convulsive seizures reveal seizure severity and to determine whether automatically computed surface EMG parameters during seizures can predict postictal generalized EEG suppression (PGES), indicating increased risk for sudden unexpected death in epilepsy. Wearable EMG devices have been clinically validated for automated detection of generalized tonic-clonic seizures. Our goal was to use quantitative EMG measurements for seizure characterization and risk assessment. Methods: Quantitative parameters were computed from surface EMGs recorded during convulsive seizures from deltoid and brachial biceps muscles in patients admitted to long-term video-EEG monitoring. Parameters evaluated were the durations of the seizure phases (tonic, clonic), durations of the clonic bursts and silent periods, and the dynamics of their evolution (slope). We compared them with the duration of the PGES. Results: We found significant correlations between quantitative surface EMG parameters and the duration of PGES ( p < 0.001). Stepwise multiple regression analysis identified as independent predictors in deltoid muscle the duration of the clonic phase and in biceps muscle the duration of the tonic-clonic phases, the average silent period, and the slopes of the silent period and clonic bursts. The surface EMG-based algorithm identified seizures at increased risk (PGES ≥20 seconds) with an accuracy of 85%. Conclusions: Ictal quantitative surface EMG parameters correlate with PGES and may identify seizures at high risk. Classification of evidence: This study provides Class II evidence that during convulsive seizures, surface EMG parameters are associated with prolonged postictal generalized EEG suppression.