Acute and sub-acute stroke lesion segmentation from multimodal MRI. (October 2020)

• Record Type: Journal Article
• Authors: Clèrigues, Albert; Valverde, Sergi; Bernal, Jose; Freixenet, Jordi; Oliver, Arnau; Lladó, Xavier
• Is Part Of: Computer methods and programs in biomedicine. Volume 194(2020)
• Publication Date: 2020-10
• Subjects: Brain -- MRI -- Ischemic stroke -- Automatic lesion segmentation -- Convolutional neural networks -- Deep learning; Medicine -- Computer programs -- Periodicals; Biology -- Computer programs -- Periodicals; Computers -- Periodicals; Medicine -- Periodicals; Médecine -- Logiciels -- Périodiques; Biologie -- Logiciels -- Périodiques; Biology -- Computer programs; Medicine -- Computer programs; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.cmpb.2020.105521
• Languages: English
• ISSNs: 0169-2607

Abstract

Highlights: We propose a deep learning method for stroke lesion segmentation from multimodal MRI. We use a combination of patches and a weighted loss function to handle class imbalance. We pre-process the data to exploit the brain symmetry between hemispheres. We analyse its performance using two tasks from the ISLES challenge. We rank first in both tasks without any dataset specific training parameter tuning Abstract: Background and objective. Acute stroke lesion segmentation tasks are of great clinical interest as they can help doctors make better informed time-critical treatment decisions. Magnetic resonance imaging (MRI) is time demanding but can provide images that are considered the gold standard for diagnosis. Automated stroke lesion segmentation can provide with an estimate of the location and volume of the lesioned tissue, which can help in the clinical practice to better assess and evaluate the risks of each treatment. Methods. We propose a deep learning methodology for acute and sub-acute stroke lesion segmentation using multimodal MR imaging. We pre-process the data to facilitate learning features based on the symmetry of brain hemispheres. The issue of class imbalance is tackled using small patches with a balanced training patch sampling strategy and a dynamically weighted loss function. Moreover, a combination of whole patch predictions, using a U-Net based CNN architecture, and high degree of overlapping patches reduces the need for additional post-processing. Results. The proposed method is evaluated using two public datasets from the 2015 Ischemic Stroke Lesion Segmentation challenge (ISLES 2015). These involve the tasks of sub-acute stroke lesion segmentation (SISS) and acute stroke penumbra estimation (SPES) from multiple diffusion, perfusion and anatomical MRI modalities. The performance is compared against state-of-the-art methods with a blind online testing set evaluation on each of the challenges. At the time of submitting this manuscript, our approach is the first method in the online rankings for the SISS (DSC=0.59 ± 0.31) and SPES sub-tasks (DSC=0.84 ± 0.10). When compared with the rest of submitted strategies, we achieve top rank performance with a lower Hausdorff distance. Conclusions. Better segmentation results are obtained by leveraging the anatomy and pathophysiology of acute stroke lesions and using a combined approach to minimize the effects of class imbalance. The same training procedure is used for both tasks, showing the proposed methodology can generalize well enough to deal with different unrelated tasks and imaging modalities without hyper-parameter tuning. In order to promote the reproducibility of our results, a public version of the proposed method has been released to the scientific community.