Preparation and spectroscopic investigations of hydroxyapatite-curcumin nanoparticles-loaded polylactic acid for biomedical application. Issue 1 (2nd January 2019)

• Record Type: Journal Article
• Authors: Hezma, A. M.; Abdelrazzak, Abdelrazek B.; El-Bahy, Gamal S.
• Is Part Of: Egyptian journal of basic and applied sciences. Volume 6:Issue 1(2019)
• Page Start: 1
• Page End: 9
• Publication Date: 2019-01-02
• Subjects: HA -- PLA -- curcumin -- and biocomposite scaffold; Science -- Periodicals; Technology -- Periodicals; Technology; Science; Science; Electronic journals; Periodicals; Periodical; 505
• DOI: 10.1080/2314808X.2019.1586358
• Languages: English
• ISSNs: 2314-808X

Abstract

ABSTRACT: The main goal of this work is to fabricate a biocomposite material of hydroxyapatite (HA) and polylactic acid (PLA) loaded with different concentrations of curcumin for using in bone tissue scaffold engineering. PLA-HA-curcumin biocomposite was prepared via the precipitation method with PLA/HA ratio of 80/20 wt% and different ratios of curcumin. The structure and surface morphology of the prepared biocomposite were studied using Fourier Transform Infrared spectroscopy (FTIR), x-ray diffraction spectroscopy (XRD), transmission electron microscope (TEM) and scanning electron microscope (SEM). The bioactivity enhancement of the prepared HA-PLA biocomposite was examined after immersion in simulated body fluid (SBF) before and after addition of curcumin. Drug release of the HA-PLA biocomposite prepared with different concentrations of curcumin was studied in phosphate buffer solution. Our data confirm the nanostructure of the prepared HA-PLA biocomposite and show good miscibility and diffusion of curcumin inside the scaffold matrix. Furthermore, curcumin supplementation effectively enhanced the bioactivity of the HA-PLA biocomposite.