Circulating Tumor DNA Biomarkers for Early Detection of Oligometastasis. Issue 2 (March 2020)

• Record Type: Journal Article
• Authors: Routman, David M.; Chera, Bhishamjit S.; Gupta, Gaorav P.
• Is Part Of: Cancer journal. Volume 26:Issue 2(2020)
• Publication Date: 2020-03
• Subjects: Biomarkers -- circulating tumor DNA -- oligometastasis -- radiotherapy; Cancer -- Periodicals; 616.994005
• DOI: 10.1097/PPO.0000000000000437
• Languages: English
• ISSNs: 1528-9117

Abstract

Abstract : Abstract: Oligometastasis represents an intermediate disease stage between localized and widely metastatic cancer. Efficient identification of patients with oligometastasis remains a barrier for accrual on clinical trials of oligometastasis-directed therapy. Here we review the prospect of circulating tumor DNA–based monitoring to promote sensitive, specific, and cost-efficient detection of cancer recurrence during posttreatment surveillance. Thus, an impetus for the development and implementation of clinical-grade circulating tumor DNA assays should be for the positive impact they will have on clinical investigations of oligometastasis-directed therapy.