Chromosome Errors in Human Eggs Shape Natural Fertility Over Reproductive Life Span. Issue 7 (July 2020)

• Record Type: Journal Article
• Authors: Gruhn, Jennifer R.; Zielinska, Agata P.; Shukla, Vallari; Blanshard, Robert; Capalbo, Antonio; Cimadomo, Danilo; Nikiforov, Dmitry; Chan, Andrew Chi-Ho; Newnham, Louise J.; Vogel, Ivan; Scarica, Catello; Krapchev, Marta; Taylor, Deborah; Kristensen, Stine Gry; Cheng, Junping; Ernst, Erik; Bjørn, Anne-Mette Bay; Colmorn, Lotte Berdiin; Blayney, Martyn; Elder, Kay; Liss, Joanna; Hartshorne, Geraldine; Grøndahl, Marie Louise; Rienzi, Laura; Ubaldi, Filippo; McCoy, Rajiv; Lukaszuk, Krzysztof; Andersen, Claus Yding; Schuh, Melina; Hoffmann, Eva R.
• Is Part Of: Obstetrical & gynecological survey. Volume 75:Issue 7(2020)
• Publication Date: 2020-07
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Surgery -- Periodicals; 618
• DOI: 10.1097/OGX.0000000000000817
• Languages: English
• ISSNs: 0029-7828

Abstract

Abstract : (Abstracted from Science 2019;365:1466–1469) While it is understood that young females (≥13 years to early 20s) and women of advancing maternal age (AMA, mid-30s or older) have reduced fertility rates, the exact mechanisms behind this feature of the fertility curve remain unclear. Because chromosomal errors and aneuploidy cause a significant amount of pregnancy loss and congenital disorders in women of advanced maternal age, meiotic error rates throughout the entire reproductive life span may shape natural fertility.