Hypoxia and Amino Acid Imaging of High-Grade Glioma: 18F-FAZA PET/CT and 11C-Methionine PET/MRI. (June 2020)

• Record Type: Journal Article
• Authors: Mapelli, Paola; Fallanca, Federico; Scifo, Paola; Barbera, Maurizio; Castellano, Antonella; Bettinardi, Valentino; Incerti, Elena; Gianolli, Luigi; Anzalone, Nicoletta; Picchio, Maria
• Is Part Of: Clinical nuclear medicine. Volume 45:Number 6(2020)
• Publication Date: 2020-06
• Subjects: 18F-FAZA -- 11C-Methionine -- PET/MRI -- glioma -- PET/CT; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000003028
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: In the present case, we report the first experience of a patient with high-grade glioma who underwent dual 18 F-FAZA PET/CT imaging for intratumoral hypoxia assessment, before treatment, and for therapy monitoring in the suspicious of recurrence, as part of a clinical research protocol. In addition, despite the diagnosis of glioblastoma, the patient at 3 years from diagnosis was alive and underwent 11 C-methionine simultaneous PET/MRI for disease monitoring after treatment, showing stability of disease. The multitracer capability of PET in assessing different and complementary metabolic features along with the use of a last-generation scanner as PET/MRI in brain oncology are here enlighten.