Clinical course of non-small cell lung cancer patients with dry pleural dissemination: Retrospective observational study. Issue 11 (March 2020)

• Record Type: Journal Article
• Authors: Kim, Woojung; Park, In Kyu; Park, Samina; Kang, Chang Hyun; Kim, Young Tae
• Other Names: Sun. YX section editor.
• Is Part Of: Medicine. Volume 99:Issue 11(2020)
• Publication Date: 2020-03
• Subjects: malignant pleural effusion -- neoplasm seeding -- non-small cell lung cancer; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000019533
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: We investigated the prognosis of patients with dry pleural dissemination (DPD) of non-small cell lung cancer (NSCLC) and the risk factors of developing to malignant pleural effusion (MPE). We retrospectively reviewed 104 patients with NSCLC and DPD, confirmed surgically from 1996 to 2016. Incidence rate and risk factors of MPE were analyzed statistically. The prognosis of NSCLC patients with MPE was evaluated using the Kaplan–Meier method. The most common histologic type was adenocarcinoma in 95 (91.3%) patients. The median follow-up duration was 65.5 months and the median survival time was 37.7 months. MPE developed in 51 (49%) patients, and the median effusion-free interval was 41.9 months. The median survival time of the patients with and without MPE was not different (41.3 vs 31.7 months, P = .16). No predictive factors for the development of MPE were identified. Fifteen (14.4%) patients underwent invasive procedures for the management of MPE. Almost half of all patients with NSCLC and DPD experienced MPE, and 14.4% patients developed symptomatic MPE requiring invasive procedures. MPE in DPD did not affect the survival in NSCLC patients.