Case report: simultaneous occurrence of multiple myeloma and non-Hodgkin lymphoma treated by CAR T therapy. Issue 16 (April 2020)

• Record Type: Journal Article
• Authors: Li, Tongjuan; Tan, Jiaqi; Chen, Liting; Kuang, Dong; Mao, Xia; Lou, Yaoyao; Zhou, Jianfeng; Zhou, Xiaoxi
• Other Names: NA. section editor.
• Is Part Of: Medicine. Volume 99:Issue 16(2020)
• Publication Date: 2020-04
• Subjects: B cell lymphoma -- B cell maturation antigen -- chimeric antigen receptor T -- CD19 -- multiple myeloma; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000019739
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Rationale: B cell lymphoma can co-occur with multiple myeloma (MM), and the prognosis in this case is usually poor. We propose the combination of CD19-chimeric antigen receptor (CAR) T cells and BCMA-CAR T cells for the treatment of such patients to obtain a superior prognosis. Patient concerns: We present a 50-year-old patient with previous B cell lymphoma and subsequent multiple myeloma (MM). Diagnosis: A diagnosis of B cell lymphoma and MM was made. Interventions: The patient was treated with a combination of haploidentical CD19-chimeric antigen receptor (CAR) T cells and BCMA-CAR T cells. Outcomes: After CAR T cell therapy, the monoclonal plasma cells in the bone marrow and M protein disappeared. Lessons: The combination therapy of CD19- and BCMA-CAR T cells is an effective measure to treat patients with concomitant or borderline cases of B cell lymphoma and MM. Abstract : Supplemental Digital Content is available in the text