Granuloma With an Underlying Lymphoma: A Diagnostic Challenge and a Wider Histologic Spectrum Including Adult T-Cell Leukemia/Lymphoma. Issue 4 (April 2020)

• Record Type: Journal Article
• Authors: Wu, Chih-Ying; Wang, Ren-Ching; Chen, Bo-Jung; Chen, Wei-Yu; Jhuang, Jie-Yang; Chang, Ming-Chih; Wu, Yu-Hung; Nakada, Norihiro; Karube, Kennosuke; Chuang, Shih-Sung
• Is Part Of: Applied immunohistochemistry & molecular morphology. Volume 28:Issue 4(2020)
• Page Start: 316
• Page End: 324
• Publication Date: 2020-04
• Subjects: adult T-cell leukemia/lymphoma -- Epstein-Barr virus -- granuloma -- granulomatous inflammation -- peripheral T-cell lymphoma.; Diagnostic immunohistochemistry -- Periodicals; Immunohistochemistry -- Periodicals; Cells -- Morphology -- Periodicals; Molecular diagnosis -- Periodicals; 616.079
• DOI: 10.1097/PAI.0000000000000731
• Languages: English
• ISSNs: 1541-2016

Abstract

Abstract : Granulomatous reaction is not uncommon in histopathology, with various etiologies in different organs and geographic regions. Lymphoma is one of the underlying causes of granuloma; and sometimes the neoplastic cells may be masked by the granulomatous reaction. In this report, we present our experience with 7 lymphoma cases of various histologic types with coexisting granuloma to show the diagnostic challenges. In all cases, a granulomatous reaction was simultaneously present with the neoplastic cells. The 7 cases included 3 cases of adult T-cell leukemia/lymphoma in the lymph node or skin including one coexisting with mycobacterial infection, 2 cases of classical Hodgkin lymphoma involving the liver, and 1 case each of systemic Epstein-Barr virus–positive peripheral T-cell lymphoma and a hepatic inflammatory pseudotumor-like follicular dendritic cell sarcoma. Three cases were initially misdiagnosed as reactive change or mycobacterial infection instead of lymphoma, and a wrong histologic lymphoma type was diagnosed in 1 case. In this report, we showed that granulomatous reaction might mask lymphomas of various histologic types; and a diagnosis of mycobacterial infection or sarcoidosis could not exclude the possibility of an underlying lymphoma. We emphasized the importance of detailed histologic examination with the aid of ancillary studies to reach a correct diagnosis and to avoid inappropriate management of the patients. Our study also broadened the spectrum of lymphoma types coexisting with granuloma.