Synthesis of 3-benzoyl-4-benzylfurans structural related to furolignans. Issue 15 (2nd August 2020)

• Record Type: Journal Article
• Authors: Tufano, Immacolata; Iesce, Maria Rosaria; Buommino, Elisabetta; Cermola, Flavio; DellaGreca, Marina
• Is Part Of: Natural product research. Volume 34:Issue 15(2020)
• Page Start: 2109
• Page End: 2115
• Publication Date: 2020-08-02
• Subjects: furolignan -- furan -- synthesis -- Friedel-Crafts reaction -- anhydride triflic -- antimicrobial activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1576040
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Furolignan-type natural products, possessing important biological properties, have been synthesized from a commercially available furan. The elaborated synthetic strategy is based on an innovative Friedel-Crafts reaction starting from an alcohol or a carboxylic acid and triflic anhydride as promoter. Through this synthetic strategy, furolignans having two different aryl groups have been obtained. The products have been evaluated for their antimicrobial properties on Gram positive and Gram negative bacteria, in order to compare their biological activities with those of natural analogues. Graphical Abstract: