Coordination polymers constructed from 5-nitro-1, 2, 3-benzenetricarboxylic acid: crystal structures and treatment effect on nephrotic syndrome by regulating intestinal flora and recovering Th17/Treg balances. Issue 8 (2nd August 2020)

• Record Type: Journal Article
• Authors: Qiu, Tingting; Yi, Xin; Xu, Lulu; Wang, Lifeng; Hu, Xihui; Li, Xiaozhong
• Is Part Of: Inorganic and nano-metal chemistry. Volume 50:Issue 8(2020)
• Page Start: 592
• Page End: 598
• Publication Date: 2020-08-02
• Subjects: Coordination polymer -- mixed-ligand -- X-ray diffraction -- nephrotic syndrome; Inorganic compounds -- Synthesis -- Periodicals; Nanostructured materials -- Periodicals; Reactivity (Chemistry) -- Periodicals; Inorganic compounds -- Synthesis; Nanostructured materials; Reactivity (Chemistry); Periodicals; 546
• DOI: 10.1080/24701556.2020.1722696
• Languages: English
• ISSNs: 2470-1556

Abstract

Abstract: Two new transition metal-based coordination polymers [Zn3 (bimb)2 (nbta)2 ] n (1, bimb = 1, 4-bis(imidazol-1-yl)-2-butene, H3 nbta = 5-nitro-1, 2, 3-benzenetricarboxylic acid) and {[Cu3 (nbta)2 (bipp)2 (H2 O)2 ](H2 O)2 } n (2, bipp = 1, 4-bis(pyridin-4-ylmethyl)piperazine) have been successfully prepared by reaction of 5-nitro-1, 2, 3-benzenetricarboxylic acid with the corresponding metal salts and the different N-donor ligands. Furthermore, the treatment effect of compounds 1 and 2 on nephrotic syndrome (NS) was evaluated and the specific mechanism was explored in this research. Firstly, to investigate the level of the Th17 cells and CD4 + CD25 + Foxp3+ regulate cells (Treg) in PBMC was detected with flow cytometry. The RT-PCR was performed to analyze the mRNA expression level of 16sRNA to determine the intestinal flora abundance.