A microporous Co(II)-MOF as a pH-responsive 5-Fu delivery system to induce human hemangioma cells apoptosis and abrogate their growth. Issue 9 (2nd May 2020)

• Record Type: Journal Article
• Authors: Wang, Qi-Qi; Yang, Zhi-Peng; Cui, Zhong-Tao; Wang, Xiao-Hui; Lin, Yao
• Is Part Of: Journal of coordination chemistry. Volume 73:Issue 9(2020)
• Page Start: 1436
• Page End: 1449
• Publication Date: 2020-05-02
• Subjects: Metal-organic framework -- polar pore surface -- 5-Fu delivery -- anticancer activity; Coordination compounds -- Periodicals; 541.2242
• DOI: 10.1080/00958972.2020.1784405
• Languages: English
• ISSNs: 0095-8972

Abstract

Abstract: A microporous metal-organic framework containing Co(II) as nodes with a polar pore surface, {[Co(SDB)(bpdh)0.5 ]}n (1 ), was formed via reaction of a –SO2 functionalized organic connector (H2 SDB = 4, 4′-sulfonyldibenzoic acid) combined with (bpdh = 2, 5-bis(3-pyridyl)-3, 4-diaza-2, 4-hexadiene), N-rich spacer under the solvothermal conditions. The diamond channels of the framework for 1 have a size of 6.1 Å along the b axis of the crystal, and the surface area of BET is 541 m 2 ·g −1 . FT-IR spectra demonstrated 5-Fu loading and ultraviolet–visible spectra showed the loading capacity of 5-Fu of 27.36%. Compared with normal tissue of pH = 7.4, the drug release in simulated cancer tissue of pH = 5.7 was gradual, showing a rational pH-responsive drug release. Clone formation experiments and CCK-8 assay confirmed the antitumor activity of 5-Fu@1a against EOMA hemangioma cells. Detection of apoptotic protein level and Annexin V-FITC/PI analysis showed that 5-Fu@1a could induce the apoptosis in caspase-dependent manner. Antitumor ability of the 5-Fu was verified by experimental data in vivo, which is consistent with the experimental data in vitro . Graphical Abstract: