Amomutsaokols A–K, diarylheptanoids from Amomum tsao-ko and their α-glucosidase inhibitory activity. (September 2020)

• Record Type: Journal Article
• Authors: He, Xiao-Feng; Wang, Hui-Mei; Geng, Chang-An; Hu, Jing; Zhang, Xue-Mei; Guo, Yuan-Qiang; Chen, Ji-Jun
• Is Part Of: Phytochemistry. Volume 177(2020)
• Publication Date: 2020-09
• Subjects: Amomum tsao-ko -- Amomutsaokols A‒K -- Diarylheptanoids -- α-Glucosidase inhibitory activity; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2020.112418
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Eleven undescribed diarylheptanoids, amomutsaokols A‒K (1 –11 ), together with 13 known ones (13 –24 ), were isolated from the active fraction of the fruits of Amomum tsao-ko . The structures of the undescribed compounds were determined by extensive 1D and 2D NMR, HRESIMS and ECD calculations. Compounds 3 –5, 7, 8, 12, 14 and 19 showed obviously α -glucosidase inhibitory activity with IC50 values ranging from 12.9 to 48.8 μM. An enzyme kinetic analysis indicated that compounds 8 and 9 were α -glucosidase noncompetitive inhibitors with K i values of 18.5 and 213.0 μM, respectively. This study supported diarylheptanoids as the active constituents of A. tsao-ko with α -glucosidase inhibitory effects. Graphical abstract: Eleven new diarylheptanoids, amomutsaokols A‒K (1 –11 ), together with 13 known ones (13 –24 ), were isolated from the fruits of Amomum tsao-ko . Compounds 3 –5, 7, 8, 12, 14 and 19 showed obviously α -glucosidase inhibitory activity with IC50 values ranging from 12.9 to 48.8 μM. Image 1 Highlights: Amomutsaokols A‒K, 11 new diarylheptanoids were isolated from A. tsao-ko. Seven compounds showed obvious α -glucosidase inhibitory activity. Compounds 8 and 9 were noncompetitive inhibitors of α -glucosidase. The K i values of compounds 8 and 9 on α -glucosidase were 18.5 and 213.0 μM.