Plasma metabolomic profiles associated with infant food allergy with further consideration of other early life factors. (August 2020)

• Record Type: Journal Article
• Authors: Ellul, Susan; Marx, Wolfgang; Collier, Fiona; Saffery, Richard; Tang, Mimi; Burgner, David; Carlin, John; Vuillermin, Peter; Ponsonby, Anne-Louise
• Is Part Of: Prostaglandins, leukotrienes, and essential fatty acids. Volume 159(2020)
• Publication Date: 2020-08
• Subjects: Birth cohort -- Fish oil -- Food allergy -- Lipids -- Metabolomics -- Vitamin D; Apo Apolipoprotein -- BH Benjamini-Hochberg -- BIS Barwon Infant Study -- BMI Body mass index -- DHA Docosahexaenoic acid -- FA Fatty acid -- FDR False Discovery Rate -- HDL High-density lipoprotein -- IDL Intermediate-density lipoprotein -- LDL Low-density lipoprotein -- MS Mass spectrometry -- NMR Nuclear magnetic resonance -- QC Quality control -- SEIFA Socio-Economic Indexes for Areas -- SES Socio-Economic Status -- SPT Skin prick test; Lipids -- Periodicals; Unsaturated fatty acids -- Periodicals; Prostaglandins -- Periodicals; Leukotrienes -- Periodicals; Fatty Acids, Unsaturated -- Periodicals; Acides gras insaturés -- Périodiques; Prostaglandines -- Périodiques; Leucotriènes -- Périodiques; Lipides -- Périodiques; 612.01577
• DOI: 10.1016/j.plefa.2020.102099
• Languages: English
• ISSNs: 0952-3278

Abstract

Highlights: An elevated linoleic acid to total fatty acid ratio is associated with infant food allergy Antenatal fish oil supplementation is associated with higher infant docosahexaenoic acid and omega-3 related fatty acids measures 25OHD3 levels are associated with an altered infant metabolomic profile Abstract: Background: Fatty acids have been implicated in early life immune development. Food allergy provides a clear phenotype of early allergic disease. Fish oil and vitamin D have immune-modulating properties. We aimed to identify the metabolomic profile of (i) infant food allergy and (ii) factors linked to food allergy in past studies such as fish oil supplementation and serum 25OHD3 levels in early life. Methods: NMR was used to quantify 73 metabolites in plasma of 1 year old infants from the Barwon Infant Study (n=485). Logistic regression models were used to examine associations between infant metabolome and food allergy in infants. Linear regression models were used to describe associations between maternal fish oil supplementation and 25OHD3 levels with infant metabolites. Results: A higher linoleic acid: total fatty acid (FA) ratio and phenylalanine level were associated with higher odds of food allergy. Antenatal fish oil supplementation was positively associated with docosahexaenoic acid (DHA) and omega-3 related metabolite levels. Postnatal 25OHD3 levels at 1 year of age were positively associated with several FA measures and creatinine and inversely with the saturated FA: total FA ratio. Only the postnatal 25OHD3 patterns persisted after adjustment for multiple comparisons. Conclusions: Infants with food allergy had altered fatty acid profiles at one year. Fish oil supplementation in pregnancy was associated with higher DHA and omega-3 related metabolites at 1 year of age. Associations were modest and the most robustly altered metabolomic profiles were with postnatal 25OHD3 levels.